The aims of this study are to apply integrated Control Strain Theory to (1) determine the extent to which adolescent and parent alcohol use predict running away; (2) determine whether youths’ relationships with parents mediates the association between alcohol use and adolescent running away; (3) examine the moderating influence of bonds to the school and conventional peers on the relationship between parent-child relationship and running away; and (4) determine whether running away in adolescence is a significant, independent predictor of alcohol use and related problems.